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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC2
All Species:
59.09
Human Site:
Y77
Identified Species:
81.25
UniProt:
P06493
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P06493
NP_001777.1
297
34081
Y77
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
Chimpanzee
Pan troglodytes
XP_001164618
264
30384
K56
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
Rhesus Macaque
Macaca mulatta
XP_001095798
297
34077
Y77
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
Dog
Lupus familis
XP_849450
297
34047
Y77
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
Cat
Felis silvestris
Mouse
Mus musculus
P11440
297
34088
Y77
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
Rat
Rattus norvegicus
P39951
297
34116
Y77
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509674
303
34737
Y77
L
M
Q
D
A
R
L
Y
L
I
F
E
F
L
S
Chicken
Gallus gallus
P13863
303
34670
Y77
L
M
Q
D
A
R
L
Y
L
I
F
E
F
L
S
Frog
Xenopus laevis
P24033
302
34513
Y77
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
Zebra Danio
Brachydanio rerio
NP_997729
302
34539
Y77
L
M
Q
E
S
K
L
Y
L
V
F
E
F
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
Y77
L
M
E
E
N
R
I
Y
L
I
F
E
F
L
S
Honey Bee
Apis mellifera
XP_393093
585
68394
Y364
L
M
E
E
T
R
L
Y
L
I
F
E
Y
L
T
Nematode Worm
Caenorhab. elegans
P34556
332
38277
F95
I
M
Q
E
N
R
L
F
L
I
F
E
F
L
S
Sea Urchin
Strong. purpuratus
XP_781415
301
34665
Y77
L
M
E
P
N
R
L
Y
L
V
F
E
Y
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
Y77
V
H
S
E
K
R
I
Y
L
V
F
E
Y
L
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
Y77
V
H
S
E
K
R
L
Y
L
V
F
E
Y
L
D
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
Y85
H
S
D
A
H
K
L
Y
L
V
F
E
F
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.5
99.3
98.6
N.A.
96.3
96.9
N.A.
95.3
90.4
84.7
81.4
N.A.
71.3
36.2
58.4
70.1
Protein Similarity:
100
88.8
99.6
99.6
N.A.
98.6
98.9
N.A.
96.6
94.3
93.3
91.7
N.A.
83.8
42.2
72.8
86.7
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
93.3
93.3
100
80
N.A.
73.3
66.6
73.3
60
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
100
100
100
93.3
Percent
Protein Identity:
N.A.
63.3
N.A.
64.9
59
N.A.
Protein Similarity:
N.A.
78.7
N.A.
79.4
76.5
N.A.
P-Site Identity:
N.A.
40
N.A.
46.6
46.6
N.A.
P-Site Similarity:
N.A.
73.3
N.A.
73.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
12
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
6
48
0
0
0
0
0
0
0
0
0
0
18
% D
% Glu:
0
0
24
36
0
0
0
0
6
0
0
95
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
6
0
0
95
0
71
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
6
12
0
0
6
0
0
0
0
0
0
6
0
0
0
% H
% Ile:
12
0
0
6
0
0
12
0
0
65
0
0
0
0
6
% I
% Lys:
0
0
0
0
12
12
0
6
0
0
0
0
0
0
0
% K
% Leu:
71
0
0
0
0
6
89
0
95
6
0
0
0
95
0
% L
% Met:
0
77
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
18
0
0
0
0
0
0
0
0
6
0
% N
% Pro:
0
0
0
6
0
0
0
0
0
0
0
0
6
0
0
% P
% Gln:
0
0
59
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
6
0
0
0
83
0
0
0
0
6
0
0
0
0
% R
% Ser:
0
6
12
0
48
0
0
0
0
0
0
0
0
0
65
% S
% Thr:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
12
% T
% Val:
12
0
0
0
0
0
0
0
0
30
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
89
0
0
0
0
24
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _